The overarching goal of Dr. Mulsant’s research work over more than two decades has been to improve the treatment of persons with severe mental disorders. He has authored and co-authored more than 320 journal articles and book chapters. He has been funded by NIMH and CIHR since 1992. His long-term scientific focus has been on designing and conducting clinical trials for “hard–to-treat” older patients with severe mental disorders: geriatric depression, psychotic depression, late–life bipolar disorder, schizophrenia, and dementia. Over the past decade, his collaborators and he have been involved in efforts to identify biomarkers associated with late-life mental disorders based on new advances in pharmacogenetics and neuroimaging. In April 2014, he received a $10M grant from Brain Canada to study the efficacy of a combination of transcranial Direct Current Stimulation (tDCS) and cognitive remediation in the prevention of Alzheimer’s disease in high-risk patients. He is also leading a new study of telephone-based integrated collaborative care to improve the outcomes of depression, anxiety, and problem drinking in primary care patients.