Department of Psychiatry

Dr. Ishrat Husain MBBS, MD (Res.), MRCPsych
Assistant Professor
Brain and Therapeutics
Dr. Ishrat Husain
Contact Info
T: (416) 535-8501 37838
Location
Centre for Addiction & Mental Health
100 Stokes Street
Toronto, ON, M6J 1H4
Appointment Status Primary
Degree/Qualification
MBBS, MD(Res.), MRCPsych
Professional Memberships
Member of Society of Biological Psychiatry (SOBP)
Member of International Society of Bipolar Disorders (ISBD)
Member of International Society of Affective Disorders (ISAD)
Member of American Psychiatric Association (APA)
Member of Ontario Medical Association (OMA)
Member of the Royal College of Psychiatrists, Royal College of Psychiatrists, London, UK
Appointments
Assistant Professor, Brain and Therapeutics, Department of Psychiatry, Toronto
Clinician Scientist and Staff Psychiatrist, General Psychiatry and Health Systems Division, CAMH
Visiting Clinical Senior Lecturer, Institute of Psychiatry, Psychology and Neuroscience, King’s College London

Dr. Ishrat Husain was raised in Toronto and completed his medical degree at St George’s, University of London in the UK. He then completed postgraduate speciality training in adult psychiatry at the world-renowned South London and Maudsley training scheme. He moved back home to Toronto in January 2018 as Clinician Scientist at CAMH and Assistant Professor at the Department of Psychiatry, University of Toronto.

Dr. Husain also holds a visiting academic post at the Institute of Psychiatry, Psychology and Neuroscience, King’s College London, Europe’s largest centre for research and postgraduate education in psychiatry, psychology, basic and clinical neuroscience and a centre for academic excellence. He completed his research doctorate here, collaborating with world leading academics in the field of mood disorders to investigate novel treatments for unipolar and bipolar depression. Dr. Husain has established academic links with centres in Canada, the UK, Africa and South Asia. He has a strong interest in Global Mental Health and is involved in capacity building and training of mental health practitioners in low and middle-income countries. He has published several articles in peer-reviewed journals and is actively involved in undergraduate and postgraduate training. Dr. Husain has been awarded research grants from organizations including the PSI Foundation and the Stanley Medical Research Institute (SMRI). His current research focuses on clinical trials of novel treatments that target established pathology in mood disorders.

Research/Teaching

Research Synopsis

Dr. Husain's primary area of research is investigating novel treatments in mood disorders by conducting clinical trials that incorporate the use of putative biomarkers to determine the neurobiological underpinnings of both major depressive disorder and bipolar disorders. His current focus is determining the role of anti-inflammatory treatments for mood disorders.

Grants

2019 – 2021 Chief Investigator: Minocycline as adjunctive treatment for treatment-resistant depression: a double blind, placebo-controlled, randomized trial. PSI Foundation. Principal Investigator: Husain MI. Collaborators: Meyer JH, Kloiber S, Carvalho AF, Daskalakis ZJ. 187,000 CAD.

2016 – 2019 Chief Investigator. Minocycline and celecoxib as adjunctive treatments of bipolar depression: a factorial design randomised controlled trial. Stanley Medical Research Institute. Grant ID: 15T-004. Principal Investigator: Husain MI. Collaborators: Chaudhry IB, Hamirani MM, Minhas FA, Kazmi A, Hodsoll J, Haddad PM, Deakin JF, Husain N, Young AH. 291,500 USD.

2019-2021 Chief Investigator. A 12-week double blind, placebo controlled, randomized controlled trial of simvastatin as an augmenting agent in treatment-resistant depression. Biomedical Research Centre at King’s College London and South London and Maudsley NHS Foundation Trust and Pakistan Institute of Learning and Living. Grant ID: N/A. Principal Investigator: Husain MI. Collaborators: Chaudhry IB, Rahman RR, Khoso AB, Deakin JF, Husain N, Young AH. 145,972 GBP.

2014-2016 Chief Investigator. Minocycline as an adjunct for the treatment of resistant depression: pilot study. Biomedical Research Centre at King’s College London and South London and Maudsley NHS Foundation Trust and Pakistan Institute of Learning and Living. Grant ID: N/A. Principal Investigator: Husain MI. Collaborators: Chaudhry IB, Rahman RR, Hamirani MM, Qurashi I, Khoso AB, Deakin JF, Husain N, Young AH. 15,000 GBP.

Publications and Awards

Recent Publications

Carvalho AF , Stubbs B, Maes M, Solmi M, Vancampfort D, Kurdyak PA, Brunoni AR, Husain MI , Koyanagi A. Different Patterns Of Alcohol Consumption And The Incidence And Persistence Of Depressive And Anxiety Symptoms Among Older Adults In Ireland: A Prospective Community-Based Study. Journal of Affective Disorders(2018), doi: 10.1016/j.jad.2018.06.041

Husain MI, Strawbridge R, Stokes PR, Young AH. Anti-inflammatory treatments for mood disorders: Systematic review and meta-analysis. J Psychopharmacol. 2017 Sep;31(9):1137-1148. doi: 10.1177/0269881117725711. Epub 2017 Aug 31.

Husain MI, Chaudhry IB, Husain N, Khoso AB, Rahman RR, Hamirani MM, Hodsoll J, Qurashi I, Deakin JF, Young AH. Minocycline as an adjunct for treatment-resistant depressive symptoms: A pilot randomised placebo-controlled trial. J Psychopharmacol. 2017 Sep;31(9):1166-1175. doi: 10.1177/0269881117724352. Epub 2017 Aug 31.

Husain MI, Chaudhry IB, Rahman RR, Hamirani MM, Mehmood N, Haddad PM, Hodsoll J, Young AH, Naeem F, Husain N. Pilot study of a culturally adapted psychoeducation (CaPE) intervention for bipolar disorder in Pakistan. International Journal of Bipolar Disorders. 2017 Dec;5(1):3.

Husain MI, Chaudhry IB, Hamirani MM, Minhas FA, Kazmi A, Hodsoll J, Haddad P, Deakin JFW, Husain N, Young AH. Minocycline and celecoxib as adjunctive treatments of bipolar depression: a study protocol for a multicentre factorial design randomised controlled trial. Neuropsychiatric Disease and Treatment. 2016 Dec 19; 13:1-8.

Honours and Awards

Merit Certificate awarded for outstanding achievement in Medical Sciences (St George’s University of London, July 2007)

Merit Certificate awarded for outstanding achievement in Clinical Sciences (St George’s University of London July 2007)