Jennifer Crosbie

Dr. Jennifer Crosbie is a Clinical Psychologist and Health Clinician Scientist within the Department of Psychiatry and the Clinical Lead of the Mental Health Access Program at SickKids. Dr. Crosbie is an Associate Scientist within the SickKids Research Institute, Neuroscience and Mental Health Program, and Assistant Professor at the University of Toronto, Department of Psychiatry. Dr. Crosbie is the recipient of the Susan J. Bradley Health Clinician Scientist Award and is an O’Brien Scholar.

Research Synopsis

Dr. Crosbie’s research and clinical work are focused on understanding the neurobiological determinants of childhood neuropsychiatric disorders, with a particular focus on attention-deficit/ hyperactivity disorder (ADHD). Four integrated domains of research create the foundation of her research program; 1) Cognition and behavioural phenomenology of ADHD and related disorders in children, youth and their families using cross sectional and longitudinal methods, 2) Understanding the genetic etiology of ADHD and other neurodevelopmental disorders, 3) Utilizing general population samples to investigate the relationship of genes and environment on pediatric psychiatric traits, health and cognition., and 4) Development of novel cognitive rehabilitation interventions for neurodevelopmental and brain based disorders.

Recent Publications

Select examples of recent publications:

Serotonin system genes and obsessive-compulsive trait dimensions in a population-based, pediatric sample: a genetic association study. Sinopoli VM, Erdman L, Burton CL, Park LS, Dupuis A, Shan J, Goodale T, Shaheen SM, Crosbie J, Schachar RJ, Arnold PD. (2019).  J Child Psychol Psychiatry. 2019 Jul 19. doi: 10.1111/jcpp.13079.  Journal of Child Psychology and Psychiatry. 
     

Roberts, S, McDonald, K, Danguecan, A, Crosbie, J, Westmacott R, Andrade, B. Dlamini, N, Williams, TS (In press).  Longitudinal academic outcomes of children with secondary attention deficit/hyperactivity disorder following pediatric stroke. Developmental Neuropsychology. Dev Neuropsychol. 2019 Jul;44(4):368-384.

Burton, C.L., Wright, L., Shan, J., Xiao, B., Dupuis, A., Goodale, T., Shaheen, S-M, Corfield, E.C., Arnold. P.D., Schachar, R.J., & Crosbie, J. (2019).  SWAN Scale for ADHD Trait-Based Genetic Research: A Validity and Polygenic Risk Study. Journal of Child Psychology and Psychiatry. 

Baribeau, D. A., Dupuis, A., Paton, T. A., Hammill, C., Scherer, S. W., Schachar, R. J. Arnold PD, Szatmari P, Nicolson R, Georgiades S, Crosbie J, Brian J, Iaboni A, Kushki A, Lerch JP, Anagnostou E. (2019). Structural neuroimaging correlates of social deficits are similar in autism spectrum disorder and attention-deficit/hyperactivity disorder: analysis from the POND Network. Translational Psychiatry, 9(1), 72.

Dupuis, A., Indralingam, M., Chevrier, A., Crosbie, J., Arnold, P., Burton, C. L., & Schachar, R. (2019). Response Time Adjustment in the Stop Signal Task: Development in Children and Adolescents. Child Development, 90(2), e263–e272.

Demontis, D., Walters, R. K., Martin, J., Mattheisen, M., Als, T. D., Agerbo, E., … Crosbie, J., … Neale, B. M. (2019). Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics, 51(1), 63–75.

Appointments

Honours and Awards

Select recent examples:

2017 Susan J. Bradley Health Clinical Scientist Award – Hospital for Sick Children

2017 O’Brien Scholar - O’Brien Scholars Program in Child & Youth Mental Health

2017 President’s Award: Hospital for Sick Children – Mental Health Access

Program Hospital for Sick Children

Grants

Selected examples of recent grants:

2019 - 2024     Principal Investigator. Canadian Institute for Health Research Project Grant Spring 2019. Spit for Science 2 Autism Spectrum Project: Harnessing the Power of Population-Based Samples for Gene x Environment Studies. Principal Investigator: Crosbie, J. Co-applicants: Arnold, P, Burton,C,  Schachar, R, Peters. P. Collaborators: Strug, L, Paterson, A, Scherer, S, Anagnostou, E, Vorstman, J. Duration: 5 years. Amount requested: $1,170,450 CDN.

2018 - 2023     Principal Investigator. Canadian Institute for Health Research Project Grant. Spit for Science 2: Genetic and environmental influences on behaviour and cognition in childhood neuropsychiatric disorders.  Principal Investigator: Crosbie, J. Co-applicants: Arnold, P, Burton,C,  Schachar, R, Peters. P. Collaborators: Strug, L, Paterson, A, Scherer, S, Vorstman, J., Goldenberg.  Duration: 5 year. Amount: $2,604,826 CDN.

2018-2023       Co-Investigator, Ontario Brain Institute “Province of Ontario Neurodevelopmental Disorders Network (POND)”. Principal Investigator: Anagnostou, E. Co-investigators: Scherer, S.W., Schachar, R.J., Szatmari, P., Crosbie, J.  Duration: 5 years. Amount: $13,000,000 CDN

2016-2021       Principal Investigator. Canadian Institute for Health Research; SPOR Networks in Chronic Disease Cognitive Rehabilitation (Mega Team) and its effects on emotional and behavioural regulation in ADHD, ASD, and CHD.  Principal Investigator: Crosbie, J. Co-investigators: Szatmari, P., Anagnostou, E., Ameis, S., McCrindle, B., Sananes, R. Duration: 5 years. Amount: $1,131,652 CDN.